Table 3. Predictors of GVL at baseline and at month 12 among participants receiving ART.
Variables | adj. OR | 95% CI | P-value | |
---|---|---|---|---|
Baseline model | Plasma viral load | 2.47 | 1.66, 3.67 | < 0.0001 |
AIC = 183.62 (N = 96) | Detectable IL-1β | 1.68 | 1.32, 2.15 | <0.0001 |
Age | 1.04 | 0.99, 1.09 | 0.11 | |
N. gonorrhoea at baseline. | 4.6 | 1.26, 16.82 | 0.021 | |
Month 12 model | Genital viral load at baseline | 0.62 | (0.12, 3.27) | 0.57 |
AIC 24.6 (N = 49) | (Log10 RNA copies/mL) | |||
IL-8 at baseline (Log10 pg/mL) | 5.47 | (0.61, 49.52) | 0.13 | |
Plasma Viral load at 12 month | 2.3 | (0.84, 6.3) | 0.1 | |
(Log10 RNA copies/mL) | ||||
MIP-1β at month 12 | 4.53 | (0.96, 21.32) | 0.06 | |
(Log10 pg/mL) |
Predictors of genital viral load ≥40 copies/mL at baseline and at month 12 were determined. Ninety six women initiating ART were included in the analysis at baseline. Forty-nine women receiving ART had viral load data available at month 12 and were included in the analysis at month 12. The variables included were:
At baseline: Plasma viral load, CD4, age, IL-8, IP-10, MIP-1b, VEGF, IL-6, GCSF, IL-1β, N. gonorrhoea, Chlamydia trachomatis, Trichomonas vaginalis, HSV2
At month 12: Use of family planning method, marital status, Trichomonas vaginalis at baseline & month 12, IL-8 at baseline & month 12, IP-10 at baseline & month 12, MIP-1b at month 12, IL-1β at month 12, IL-1RA at month 12, IL-6 at month 12, Genital VL at baseline, plasma VL at month 12.
AIC: Aikaike Information criteria.