Table 2. Study Medications.
| Trial (ref#) | ASA, % | ADP-antagonist, % | Clopidogrel, % | Prasugrel, % | Ticagrelor, % | Glycoprotein IIb/IIIa inhibitor, % | Upstream anti-coagulation | Unfractionated heparin dose (units/kg) |
|---|---|---|---|---|---|---|---|---|
| Bivalirudin plus a bail-out glycoprotein IIb/IIIa inhibitor versus heparin plus a bail-out glycoprotein IIb/IIIa inhibitor: 47/45 | ||||||||
| MATRIX [29] | NR | 83/81 | 100/100 | 36/37* | 36/37* | 4.6/25.8 | 33% received heparin | 100 |
| BRIGHT [30] | 100/100 | 100/100 | 100/100 | 0/0 | 0/0 | 4/6 | None | 100 |
| NAPLES III [31] | 100/100 | 100/100 | 100/100 | NR | NR | 0.5/1.3 | None | 70 |
| ACRIPAB [32] | 100/100 | 100/100 | 12/10 | 0/0 | 0/0 | 0/0 | None | 60 |
| HEAT-PPCI [33] | 99/100 | 99/99 | 50/50 | 27/28 | 61/63 | 14/16 | None | 70 |
| EUROMAX [34] | 100/100 | 98/98 | 100/100 | 31/44 | 19/6 | 8/25 | None | 100 † |
| Xiang et al. [35] | 100/100 | 100/100 | 100/100 | 0/0 | 0/0 | 0.9/3.7 | None | 130 |
| SWITCH III [36] | 100/100 | 100/100 | 100/100 | 0/0 | 0/0 | 4/12 | Fondaparinux within 24 hours prior to PCI | 60 |
| ARMYDA-7 BIVALVE [37] | 100/100 | 100/100 | 100/100 | 0/0 | 0/0 | 12/14 | None | 75 |
| ARNO [38] | 100/100 | 100/100 | 100/100 | 0/0 | 0/0 | 15/28 | None | 100 |
| ISAR-REACT 3 [39] | 100/100 | 100/100 | 100/100 | 0/0 | 0/0 | 0.2/0.2 | None | 140 |
| Bivalirudin plus a routine glycoprotein IIb/IIIa inhibitor versus heparin plus a routine glycoprotein IIb/IIIa inhibitor: NR | ||||||||
| Desphande et al. [40] | NR | NR | 100/100 | NR | NR | 100/100 | None | 70 |
| TENACITY [41] | 100/100 | 100/100 | 68/68 | 0/0 | 0/0 | 100/100 | NR | 50 |
| ACUITY-PCI [42] | 98/98 | 68/68 | 55/57 | 0/0 | 0/0 | 97/97 | Up to 2 doses of heparin | 60* |
| REPLACE-1 [43] | 100/100 | 55/57 | 0/0 | 0/0 | 71/73 | None | 60–70 | |
* Prasugrel and ticagrelor combined together
† Enoxaparin 1 mg/kg twice daily could be used instead of unfractionated heparin
Data are formatted as bivalirudin arm/ unfractionated heparin arm
ADP = adenosine diphosphate; ASA = aspirin; NR = not reported; PCI = percutaneous coronary intervention