Table 1. Baseline demographics and smoking behaviors in the screened population (N = 1026).
| RS16969968 | ||||
| GG | GA | AA | P | |
| n (screened) a | 370 | 506 | 150 | |
| Cigarettes per day | 19.8 (18.9–20.7) | 20.2 (19.6–20.9) | 21.0 (19.2–22.2) | 0.30 |
| CO levels *only ITT | 23.5 (22.2–24.8) | 25.8 (24.5–27.0) | 24.9 (22.4–27.3) | 0.05 |
| Cotinine (ng/mL) | 219.6 (209.4–229.8) | 242.0 (232.3–251.6) | 269.0 (252.5–285.4) | <0.0001 |
| 3'-Hydroxycotinine (ng/mL) | 91.0 (84.9–97.1) | 93.7 (88.9–98.5) | 116.4 (104.3–128.5) | <0.0001 |
| Sum of Cotinine and 3'-Hydroxycotinine (ng/mL) | 311.1 (296.3–325.8) | 336.1 (322.8–349.3) | 385.3 (359.7–411.0) | <0.0001 |
| FTND | 5.2 (5.0–5.4) | 5.4 (5.1–5.8) | 5.4 (5.1–5.8) | 0.23 |
| NMR | 0.42 (0.40–0.45) | 0.40 (0.39–0.42) | 0.43 (0.40–0.47) | 0.21 |
| Sex (% Female) | 41% | 44% | 42% | 0.67 |
| Age (Years) | 46.3 (45.2–47.5) | 46.1 (45.1–47.1) | 44.8 (42.8–46.7) | 0.33 |
| BMI (Kg/m2) | 29.1 (28.5–29.7) | 28.4 (27.9–28.9) | 29.5 (28.4–30.6) | 0.08 |
| RS588765 | ||||
| CC | CT | TT | P | |
| n (screened) b | 360 | 511 | 155 | |
| Cigarettes per day | 20.5 (19.6–21.2) | 20.2 (19.4–20.9) | 19.6 (18.6–20.6) | 0.56 |
| CO levels *only ITT | 25.4 (23.9–26.9) | 24.7 (23.5–25.8) | 24.0 (21.9–26.1) | 0.52 |
| Cotinine (ng/mL) | 243.8 (232.9–254.6) | 238.7 (229.2–248.2) | 220.7 (204.9–236.6) | 0.07 |
| 3'-Hydroxycotinine (ng/mL) | 99.7 (93.2–106.3) | 96.2 (90.9–101.4) | 86.9 (78.7–95.2) | 0.09 |
| Sum of Cotinine and 3'-Hydroxycotinine (ng/mL) | 344.2 (328.4–360.1) | 335.3 (321.9–348.7) | 307.7 (285.6–329.7) | 0.04 |
| FTND | 5.4 (5.1–5.6) | 5.3 (5.1–5.5) | 5.3 (5.0–5.6) | 0.87 |
| NMR | 0.41 (0.39–0.43) | 0.42 (0.40–0.44) | 0.41 (0.37–0.44) | 0.81 |
| Sex (% Female) | 40% | 46% | 38% | 0.91 |
| Age (Years) | 46.3 (45.1–47.4) | 46.2 (45.2–47.2) | 44.5 (42.8–46.3) | 0.22 |
| BMI (Kg/m2) | 29.0 (28.4–29.6) | 28.6 (28.1–29.1) | 29.2 (28.2–30.1) | 0.41 |
| RS578776 | ||||
| GG | GA | AA | P | |
| n (screened) c | 572 | 396 | 58 | |
| Cigarettes per day | 20.3 (19.7–20.9) | 19.9 (19.1–20.7) | 20.7 (18.4–23.1) | 0.61 |
| CO levels *only ITT | 24.8 (23.6–25.9) | 24.8 (23.5–26.1) | 25.1 (20.3–29.8) | 0.99 |
| Cotinine (ng/mL) | 246.4 (237.3–255.4) | 230.9 (220.9–40.9) | 200.7 (176.3–224.2) | 0.002 |
| 3'-Hydroxycotinine (ng/mL) | 99.6 (94.6–104.7) | 91.9 (86.0–97.9) | 88.5 (75.2–101.9) | 0.09 |
| Sum of Cotinine and 3'-Hydroxycotinine (ng/mL) | 346.0 (333.1–358.9) | 323.8 (309.5–338.2) | 288.8 (254.7–322.9) | 0.005 |
| FTND | 5.4 (5.2–5.5) | 5.3 (5.1–5.4) | 5.4 (4.8–6.0) | 0.68 |
| NMR | 0.42 (0.40–0.43) | 0.40 (0.39–0.43) | 0.46 (0.40–0.52) | 0.16 |
| Sex (% Female) | 44% | 42% | 38% | 0.70 |
| Age (Years) | 45.0 (44.1–46.0) | 47.1 (46.1–48.2) | 47.3 (44.4–50.2) | 0.01 |
| BMI (Kg/m2) | 28.8 (28.2–29.2) | 29.0 (28.5–29.6) | 28.1 (26.8–29.5) | 0.51 |
a RS16969968: there were 250, 320 and 84 intent-to-treat smokers in the GG, GA and AA group respectively.
b RS588765: there were 219, 325, 110 intent-to-treat smokers in the CC, CT and TT group respectively.
c RS578776: there were 359, 260, 35 intent-to-treat smokers in the GG, GA and AA group respectively.
NMR = nicotine metabolite ratio. FTND = Fagerstrom Test for Nicotine Dependence.