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. 2015 May 26;10(5):e0128174. doi: 10.1371/journal.pone.0128174

Fig 8. Interactome for CO networks.

Fig 8

Interactome for E-CO (A) or L-CO (B) selected hubs (depicted in blue), VIPs (depicted in red) and high-hubs (depicted in green) using MINT and IntAct databases. Node size is related to node degree (number of links). Links in red represent the first and second node connections, for E-CO, or first, second and third node connections, for L-CO, centered in all hubs, VIPs and high-hubs, except FTSJ1 for L-CO. Node shapes and border colors represent biological processes, as follows: parallelogram for apoptosis; parallelogram with pink border for ubiquitination; octagon for autophagy; circle with pink or green or yellow border stand for cell processes or cytoskeleton or transcriptional regulation respectively; diamond for inflammation; triangle for ion binding; triangle with red border stand for ion channel; rectangle for neuroglia processes; rectangle with red or pink stand for neuroprotection or response to oxidative stress respectively; hexagon for neuronal development; vee for synaptic transmission.