Table 1. Initial and estimated parameter values for all patients.

Parameter	InitialValue	Low Limit	High Limit	Fitted values mean ± SD
				Model 1	Model 2
Ag RM [nmol] † ¬	-	-	-	21±14	17±13
Ag B [nmol] † ¬	-	-	-	0.58±0.39	0.50±0.38
Ag L [nmol] †	0.15	0.001	2	0.31±0.26	0.33±0.27
Ag S [nmol] †	0.15	0.001	2	0.22±0.19	0.25±0.30
ex l [unity] ‡	0.19	0	1	0.235±0.089	0.226±0.091
ex s [unity] ‡	0.04	0	1	0.107±0.048	0.098±0.038
f RM [%] #	3	0.01	10	0.67±0.21	0.73±0.24
cRM [unity] ||	1.0	0.5	3	1.22±0.33	1.20±0.34
λ db [1/min 10 –5 ] §	7	1	10	6.8±1.7	6.8±1.7
r im [unity] **	0.9	0.5	Individual	0.801±0.090	0.806±0.098
V serum [l] ††	Individual	1.0	10.0	2.99±0.62	3.00±0.63

All additional model parameters are fixed and their values are presented in S1 Text.

^† Ag_B, Ag_RM, Ag_L and Ag_S = amount of CD66 antigens in the blood, red marrow, liver and spleen, respectively.

^¬ = Ag_RM and Ag_B are calculated according to Eqs (1–4) based on Ag_L and Ag_S.

^‡ Fractions of unspecific (extra vascular delay compartment) uptake for liver ex_l and spleen ex_s.

^# f_RM = relative blood flow to the red marrow.

^|| c_RM = individual correction of the mean scaling factor [9] from drawn region of interest over Lumbar spine (L2-L4) to total red marrow activity.

^§ λ_db = degradation rate of bound antibody.

^** r_im = immunoreactivity with lower and higher limits [29].

^†† V_serum = total serum volume (Bayesian term with standard deviation as described in the methods section).