Table 3. Overview of approaches of different complexity.

Kinetic Model	Assumptions	Corrections performed
Sum of exponential functions	AgRM † >> Amount Ab #	none
	RM ‡ scaling is correct
	r || im, pre-therapeutic = rim, therapeutic
PBPK	AgRM >> Amount Ab	for inadequate RM scaling
	rim, pre-therapeutic = rim, therapeutic
PBPK §	AgRM ~ Amount Ab	for inadequate RM scaling
	rim, pre-therapeutic = rim, therapeutic	for different amount Ab
	rim, pre-therapeutic ~1	for residual amount Ab
PBPK ** Improved model	AgRM ~ Amount Ab	for inadequate RM scaling
		for different amount Ab
	rim, pre-therapeutic = rim, therapeutic	for residual amount Ab
		for half and non-reactive Ab

^†Ag_RM = number of antigens in the red marrow

^‡RM = red marrow

^# Ab = antibody

^||r_im = immunoreactivity

^§ = recently developed PBPK model [3] based on data sets of 8 patients

^** = presented refined PBPK model based on data sets of 27 patients