Table 1. Performance of urine LAM test overall and stratified by HIV status compared with gold standard of bacteriologically-confirmed TB.
Group | Prevalence of TB | Prevalence of positive LAM | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|---|---|
% (n) | % (n) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | |
Overall (n = 844) | 3.9 (33) | 0.6 (5) | 3.0 (0.1–15.8) | 99.5 (98.7–99.9) | 20.0 (0.5–71.6) | 96.2 (94.7–97.4) |
HIV-positive (n = 212) | 6.6 (14) | 1.9 (4) | 7.1 (0.2–33.9) | 98.5 (95.6–99.7) | 25.0 (0.6–80.6) | 93.8 (89.5–96.6) |
HIV-negative (n = 632) | 3.0 (19) | 0.2 (1) | 0 (0–17.6) | 99.8 (99.1->99.9) | 0 (0–97.5) | 97.0 (95.3–98.2) |
NPV = negative predictive value; PPV = positive predictive value; CI confidence interval
27 participants with possible TB have been excluded from this analysis