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. 2015 May 26;10(5):e0127953. doi: 10.1371/journal.pone.0127953

Fig 6. Quick-then-stable Parkinsonian symptoms.

Fig 6

(A) Kurlan Scores of monkeys administered MPP+ (N = 3) or saline (N = 2) directly to the SNc and striatum. One day after the infusion operation, the Kurlan scores of the MPP+ infused monkeys rose markedly, followed by a partial fall into a stable plateau, while control monkeys recovered quickly (#. P = 0.032). The Kurlan scores of the MPP+ infused monkeys maintained a plateau for 28 weeks and were significantly higher than controls (main effect of group, *. P = 0.012). The scores of both MPP+ and control monkeys showed no changing trend (main effect of time, P = 0.434) and were parallel (interaction effect of time and group, P = 0.396). (B) Stable individual PD symptom scores. Specific items related to typical symptoms of PD in the Kurlan scale also showed long-term stabilization. The grading of bradykinesia and posture, but not tremor, had significant differences between MPP+ and control monkeys (*. P = 0.007 and P = 0.001, respectively).