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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Mar 25;286(1):1–9. doi: 10.1016/j.taap.2015.03.019

Figure 6.

Figure 6

Effect of ASK1 inhibitor GS-459679 post-treatment against APAP hepatotoxicity at 24 h. Mice were treated with 500 mg/kg N-acetylcysteine (NAC) (A), 30 mg/kg ASK1i (B) and the combination of both (C) either 1.5 or 3 h after 300 mg/kg of APAP administration. The vehicle for NAC was PBS, for ASK1i was 55% PEG, and for ASK1i+NAC it was PBS+55%PEG. Plasma ALT activities and the areas of necrosis were quantified. Data represent means ± SE of 3–5 animals per group and time point. *P<0.05 compared with the respective APAP+Vehicle treated group.