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. 2015 May 26;131(21):1861–1871. doi: 10.1161/CIRCULATIONAHA.115.015308

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© 2015 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Fibroblast growth factor (FGF) 21 deficiency worsens lipid profiles and exacerbates inflammation in apolipoprotein (apo) E^−/− mice. ApoE^−/−FGF21^−/− (DKO) and apoE^−/− mice fed with standard chow were euthanized at 24 weeks after birth. Plasma samples were collected for measurement of triglycerides (TG; A), total cholesterol (TC; B), high-density lipoprotein (HDL; C), low-density lipoprotein (LDL; D), and very LDL (VLDL; E). F, The mRNA expression of intercellular adhesion molecule-1 (ICAM-1) vascular cell adhesion protein-1 (VCAM-1), tumor necrosis factor-α (TNFα), and monocyte chemotactic protein-1 (MCP-1) in aortic tissue, as well as (G–J) plasma levels of these proinflammatory chemokines and cytokines, were measured with real-time polymerase chain reaction and ELISA, respectively. n=6 to 7. Data are presented as dot plots with the line indicating the median. The Mann-Whitney U test was used for comparison of 2 groups.