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. 2015 May 26;131(21):1861–1871. doi: 10.1161/CIRCULATIONAHA.115.015308

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© 2015 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Recombinant mouse fibroblast growth factor (FGF) 21 and adiponectin (ADN) attenuate the atherosclerotic plaque formation in apolipoprotein E^−/−FGF21^−/− (DKO) mice. Eight-week-old DKO mice were treated with recombinant mouse FGF21 (0.1 mg/kg per day), adiponectin (10 mg/kg per day), or vehicle by daily intraperitoneal injection for a period of 16 weeks. A and B, Plasma levels of adiponectin and its mRNA expression in epididymal adipose tissues (EPAT), subcutaneous (SAT), perivascular (PVAT), and perirenal (PRAT) adipose tissues. C, En face staining of entire aortas with oil red O. D and E, Cross-section analysis of aortic sinuses and brachiocephalic arteries with oil red O, respectively. n=6 to 7. Data are presented as dot plots with the line indicating the median. The Mann-Whitney U test was used to compare 2 groups (A and B). The global significance among 3 groups was determined by Kruskal-Wallis test, followed by pairwise comparisons with the Dunn-Sidak procedure (C–E).