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. 2015 May 26;131(21):1861–1871. doi: 10.1161/CIRCULATIONAHA.115.015308

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© 2015 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Differential effects of fibroblast growth factor (FGF) 21 and adiponectin on lipid profiles and atherosclerotic plaque composition in apolipoprotein E^−/−FGF21^−/− (DKO) mice. DKO mice were treated with recombinant mouse FGF21, adiponectin (ADN), or vehicle for 16 weeks as in Figure 3. A, Immunohistological analysis of atherosclerotic lesion areas in aortic sinuses with antibodies against the smooth muscle marker α-actin, the macrophage marker F4/80, or with Masson trichrome staining for the collagen composition as indicated. B–F, The mRNA expression of several proinflammatory chemokines and cytokines in the aortic sinus and their plasma levels as determined by real-time polymerase chain reaction and ELISA, respectively. G, Cholesterol ester content in the brachiocephalic arteries. H and I, Plasma cholesterol and triglyceride levels in DKO mice treated with recombinant mouse (rm) FGF21, ADN, or vehicle, respectively. n=5 to 7. Data are presented as dot plots with the line indicating the median. The global significance among 3 groups was determined by Kruskal-Wallis test, followed by pairwise comparisons with the Dunn-Sidak procedure.