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. 2015 May 26;131(21):1861–1871. doi: 10.1161/CIRCULATIONAHA.115.015308

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© 2015 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 7. — Effects of fibroblast growth factor (FGF) 21 and adiponectin (ADN) on several key transcription factors involved in cholesterol metabolism. The liver samples from apolipoprotein (apo) E^−/− mice or apoE^−/−FGF21^−/− (DKO) mice treated with recombinant mouse FGF21, ADN, or vehicle as in Figure 4 were subjected to real-time polymerase chain reaction or Western blot analysis. A and B, The relative mRNA and protein expression levels of liver X receptor (LXR) α, farnesoid X receptor (FXR), and sterol regulatory element-binding protein (Srebp)-1. C and D, The relative mRNA and protein expression of Srebp-2. E and F, The DNA binding activities of Srebp-1 and Srebp-2 in the nuclear extracts of liver tissues. n=5 to 7. Data are presented as dot plots with the line indicating the median. The global significance among 4 groups was determined by Kruskal-Wallis test, followed by pairwise comparisons with the Dunn-Sidak procedure.