Table 2. Brain regions showing significantly lower glucose metabolism and gray matter in AD-converted MCI compared to non-converted MCI.

Neuroimaging	Region*	MNI coordinates (mm)			Brodmann area	Z score	The number of voxels within cluster	Uncorrected P value
		x	y	z
FDG-PET
Left	Middle frontal gyrus	-24	24	36	8	3.51	267	<0.001
Right	Superior frontal gyrus	22	-12	76	6	3.45	143	<0.001
Left	Uncus	-20	6	-30	28	3.44	662	<0.001
Left	Medial frontal gyrus	-6	68	-2	10	3.33	117	<0.001
Right	Inferior parietal lobule	66	-36	40	40	3.31	157	<0.001
Left	Paracentral lobule	-14	-30	52	6	3.28	178	<0.001
Left	Superior frontal gyrus	-12	-20	80	6	3.25	184	<0.001
Left	Lingual gyrus	-8	-88	-24	18	3.21	113	<0.001
Left	Inferior frontal gyrus	-56	6	34	9	3.18	270	<0.001
Right	Precuneus	14	-68	44	7	3.11	145	<0.001
Right	Inferior parietal lobule	34	-48	56	40	3.01	96	0.001
Right	Uncus	20	6	-24	34	3.01	85	0.001
Right	Sub-gyral	18	-32	58	4	2.89	54	0.002
Right	Cingulate gyrus	6	-36	42	31	2.83	63	0.002
MRI
Right	Subcallosal gyrus	16.5	9	-15	34	3.44	821	<0.001
Right	Cuneus	24	-90	19.5	18	3.13	70	<0.001
Left	Middle frontal gyrus	-27	-90	19.5	8	3.12	316	<0.001
Right	Precuneus	12	-61.5	40.5	7	3.06	66	0.001
Left	Precentral gyrus	-57	-12	43.5	6	3.04	96	0.001
Right	Inferior frontal gyrus	45	30	-7.5	47	3.01	56	0.001
Right	Medial frontal gyrus	12	-4.5	64.5	6	2.93	106	0.002
Right	Middle temporal gyrus	66	-7.5	-6	21	2.89	78	0.002

^*Brain regions were transformed to Talairach atlas from MNI coordinates. AD, Alzheimer's disease; MNI, Montreal Neurological Institute; FDG-PET, fluorodeoxyglucose-positron emission tomography.