Fig. 2.
Immunohistochemical staining of AFP, CD133 and EpCAM in oval cells. At low magnification, oval cell hyperplasia appears as increased cellularity in portal areas (A). Higher magnification reveals that centrilobular hepatocyte hypertrophy is also present. Some oval cells form glandular structures resembling bile ducts (a). Oval cell proliferations can be seen bridging between adjacent portal areas. Oval cells showed cytoplasmic expression of AFP (B, b) and clear membrane expression of CD133 (C, c) and EpCAM (D, d)