Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 9;28(2):79–87. doi: 10.1293/tox.2014-0047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©2015 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

PMC Copyright notice

Fig. 3. — Immunohistochemical staining of EGFR, TGFα, STAT3 and p-STAT3 in normal bile ducts, oval cells, CF and ICC. Normal bile ducts showed weak membrane or cytoplasmic staining of EGFR (A1). Oval cells (A2) and bile ducts (A3) in CF show membrane aggregation of EGFR expression. Malignant glands in the ICC exhibited strong membrane staining of EGFR (A4). Normal bile ducts showed weak cytoplasmic staining of TGFα (B1). Elevated TGFα expression was detected in oval cells (B2). Strong cytoplastic staining of TGFα was detected in the bile ducts in CF (B3) as well as in the malignant glands in the ICC (B4). Normal bile ducts showed weak nuclear p-STAT3 expression (C1). Elevated p-STAT3 expression was detected in oval cell (C2). Strong nuclear staining of p-STAT3 was detected in the bile ducts in CF (C3) as well as in the malignant glands in the ICC (C4). Normal bile ducts (D1), oval cells (D2) and bile ducts in CF (D3) showed weak cytoplastic staining of STAT3. some hepatocellular nuclei seem positive for STAT3. Some cases of ICC showed strong cytoplastic and nuclear staining of STAT3 (D4).