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. 2015 Mar 1;28(2):109–120. doi: 10.1293/tox.2014-0061

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©2015 The Japanese Society of Toxicologic Pathology

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Fig. 5. — Histopathology with H & E stain (A and D) and immunohistochemistry of β-catenin (B and E) and Ki-67 (C and F) in dysplasia of mice from the BP/DSS group. Figs. (A) to (C) and Figs. (D) to (F) are serial sections of different dysplasias, respectively. Dysplasia was characterized by irregular crypt branching and distortion of the crypt architecture. β-catenin was localized on the cell membrane of most dysplastic foci (E) and distributed in the nucleus and/or cytoplasm of a small number of dysplastic foci (B). Ki-67-positive cells were diffusely distributed in dysplastic foci (C and F).