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. 2015 Mar 1;28(2):109–120. doi: 10.1293/tox.2014-0061

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©2015 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 7. — Histopathology with H & E stain and immunohistochemistry of β-catenin and Ki-67 in the colonic mucosa of mice from the vehicle group (A–C) and BP group (D–F) and in dysplasias (G–I) and adenomas (J–L) of mice from the DSS group. No obvious histological changes were found in the vehicle (A) and BP group (D). Histological characteristics of dysplastic foci (G) and adenomas (J) found in the DSS group were similar to those observed in the BP/DSS group. β-catenin was localized on the cell membrane of the normal mucosal cells in the vehicle (B) and BP groups (E) and dysplastic foci (H) in the DSS group. The β-catenin was distributed in the nucleus and cytoplasm of adenomas (K) in the DSS group. Ki-67-positive cells were mainly localized in the lower zone of normal colonic crypts (C and F) and in diffusely distributed dysplastic foci (I) and adenomas (L) in the DSS group.