Individual fMRI responses during 5 and 100% contrast in patients P4 and P5. Representative coronal slices demonstrating the striate (left column) and extrastriate cortex (middle column) in two patients (P4 and P5). Both patients have sustained V1 damage to the left hemisphere. The top row in each case demonstrates stimulation of the sighted field, and blind field responses are shown below. The far right column depicts activity corresponding significantly to a linear relationship with increasing contrast. Activation is superimposed on representative axial slices, centered on the peak voxel. Mixed-effects analyses, p < 0.001 uncorrected for a priori ROIs; elsewhere, cluster corrected, p < 0.05. Results displayed on T1-weighted structural images.