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. 2015 May 27;35(21):8245–8257. doi: 10.1523/JNEUROSCI.4486-14.2015

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Copyright © 2015 the authors 0270-6474/15/358245-13$15.00/0

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Figure 8. — Contribution of purinergic signaling to flow/pressure-evoked increases in PA tone. A, Representative trace showing diameter changes in response to flow increases (↑Q) before and after bath application of suramin [500 μmol/L; a, d: steady-state (s-s) tone; b, e: peak constriction at stimulus (↑Q) onset; c, f: tone at the end of ↑Q stimulus; g: maximum diameter in zero Ca²⁺ + papaverine]. B, Averaged diameter (percentage from maximum) changes in response to ↑Q before and after suramin perfusion. C, Averaged s-s tone (percentage from maximum) before and after suramin perfusion. D, Averaged Δ tone (percentage) at the onset and end of the ↑Q stimulus. E, Representative trace (left) and average diameter (right) changes in response to ↑Q, before and after high ATP loading into the astrocytic syncytium (a, b: s-s tone; c: peak constriction at stimulus (↑Q) onset; d: tone at the end of ↑Q stimulus; e: maximum diameter in zero Ca²⁺ + papaverine). F, Averaged s-s tone (percentage from maximum) before and after suramin perfusion. G, Averaged Δ tone (percentage) at the onset and end of the ↑Q stimulus. *p < 0.05, **p < 0.01.