Table 1.
Ref. | Main findings |
Johnson et al[1] | Ovarian GSCs are observed within the ovarian surface epithelium and provide the adult mouse ovary with oocytes |
Johnson et al[25] | GSCs are detected in mouse bone marrow and provide the postnatal mouse ovary with oocytes |
Kerr et al[14] | The follicle numbers remain constant in ovaries of juvenile and early adult mice. Follicle renewal in postnatal and adult mouse ovaries is suggested |
Zou et al[29] | Mouse ovarian GCS are isolated by immunoselection and characterized. Ovarian GCSs transplanted into ovaries of infertile mice undergo oogenesis and produce offspring |
Pacchiarotti et al[30] | The adult mouse ovarian GSCs are isolated by FACS. Long-term expanded mouse ovarian GSCs maintain their characteristics, telomerase activity and express germ cell and stem cell markers |
White et al[7] | The ovarian GSCs are isolated by FACS. Xenotransplantation of human GCSs into NOD-SCID mice leads to the formation of follicles containing oocytes |
Zhang et al[32] | No mitotically active female GSCs exist in postnatal mouse ovaries |
Lei et al[33] | The adult female mouse ovary does not contain active ovarian GSCs. The number of follicles produced during fetal development is sufficient to provide ovaries with oocytes in adult life |
Park et al[39] | Existence of mitotically active germ cells in the postnatal mouse ovary demonstrated by a genetic approach coupled with a GSCs selection strategy |
GSCs: Germline stem cells; FACS: Fluorescence-activated cell sorting.