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. 2014 Dec 16;16(3):664–674. doi: 10.1208/s12249-014-0249-x

Table III.

Extraction Solvents and Analytical Techniques Used in the Extraction Studies

Solvents Water at pH 2.5 (HCl/KCl mixture)
Water at pH 9.5 (phosphate buffer)
Water
Isopropyl alcohol (IPA) to water (1:1)
IPA (spectroscopic grade)
Dichloromethane (DCM) (spectroscopic grade)
Hexane or Iso-hexane (spectroscopic grade)
Analytical techniques Gas chromatography/mass spectrometry (GC/MS)
Gas chromatography/flame ionization detector (GC/FID)
Liquid chromatography/mass spectrometry (LC/MS)
Liquid chromatography/ UV detection (LC/UV)
Inductively coupled plasma/mass spectrometry (ICP/MS)