Table I.

Composition of Formulations F1 to F15

Formulation no.	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14	F15
Ingredients	Quantity in mg per tablet
	Fast-release coat
Zolpidem tartrate	6. 25	6.25	6.25	6.50	6.50	6. 25	6.25	6.25	6.50	6.25	6. 25	6.25	6.25	6.50	6.50
SSG	8.40	8.40	8.40	8.40	10.5	8.40	8.40	8.40	8.40	10.5	8.40	8.40	8.40	8.40	10.5
PH 102	90	90	90	90	90	90	90	90	90	90	90	90	90	90	90
LubriTose AN	105.35	105.35	105.35	105.10	103	105.35	105.35	105.35	105.10	103	105.35	105.35	105.35	105.10	103
Total weight	210	210	210	210	210	210	210	210	210	210	210	210	210	210	210
	Slow-release core
Zolpidem tartrate	6.25	6.25	6.25	6.00	6.00	6.25	6.25	6.25	6.00	6.00	6.25	6.25	6.25	6.00	6.00
HPMC K100M	7	14	10.5	10.5	10.5	–	–	–	–	–	–	–	–	–	–
HPMC K15M	–	–	–	–	–	7	14	10.5	10.5	10.5	–	–	–	–	–
HPMC K4M	–	–	–	–	–	–	–	–	–	–	7	14	10.5	10.5	10.5
Lactose monohydrate	50	43	46.5	46.75	46.75	50	43	46.5	46.75	46.75	50	43	46.5	46.75	46.75
Tartaric acid	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
Magnesium stearate	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75
Total weight	70	70	70	70	70	70	70	70	70	70	70	70	70	70	70
Total weight of press-coated tablet	280	280	280	280	280	280	280	280	280	280	280	280	280	280	280