Figure 3.

Schematic overview of study-specific results. (A) In the sACC, both high-alexithymic groups (NC-highDD and MDD) show a comparable pattern of negative IA-related activity in the supragenual anterior cingulate cortex (sACC, see also Figures 2A,C). Low TAS-DD scorers, however, show positive IA-related activity in the sACC (see also Figure 2C). (B) Comparing NC-highDD and NC-lowDD, participants with high alexithymia show greater positive BOLD responses in the insula during IA. As both groups consist of participants without psychopathological symptoms, this pattern may represent the typical association between alexithymia and IA-related activity in the insula. When comparing groups that show similar TAS-DD scores (NC-highDD and MDD), however, depressed patients show significantly lower IA-related activity in the insula (see also Figure 2B).