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. 2015 May 27;6:107. doi: 10.3389/fphar.2015.00107

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Copyright © 2015 Lumen, McNally, George, Fisher and Loizou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lowry plot of the quantitative global sensitivity analysis results of Gaussian Emulation processes. The total effect of a parameter comprised the main effect (black bar) and any interactions with other parameters (gray bar) given as a proportion of variance. The ribbon, representing variance due to parameter interactions, is bounded by the cumulative sum of main effects and the minimum of the cumulative sum of the total effects for model predicted levels of maternal free thyroxine levels at steady state. Red line denotes the model parameters with variances and/or total effect greater than 0.5%.