Table 3.
Global sensitivity analysis parameter inputs and quantitative output indices.
| Parameters | Lower bound | Upper bound | Variance (%) | Total effect |
|---|---|---|---|---|
| CLF_UIM* | 7.87E-02 | 2.11E-01 | 17.60 | 23.00 |
| KMNIS_I* | 1.33E+04 | 4.46E+04 | 12.00 | 15.70 |
| VMAXNISF_THY_MI* | 1.22E+03 | 5.64E+03 | 12.00 | 17.00 |
| KDEGT4F_MI* | 1.03E-04 | 2.52E-04 | 10.20 | 13.60 |
| FRCONVT4_MI* | 5.67E-05 | 1.14E-04 | 8.03 | 10.10 |
| BW_M* | 5.69E+01 | 8.33E+01 | 7.57 | 10.20 |
| VDFT4_MI | 7.69E-02 | 1.63E-01 | 6.45 | 8.05 |
| QFTHY_MI | 5.43E-03 | 2.66E-02 | 5.58 | 9.23 |
| QFC_MI | 9.48E+00 | 2.17E+01 | 2.15 | 3.76 |
| CLFT4_MI | 5.66E-05 | 3.13E-04 | 1.77 | 3.34 |
| KPRODT4F_MI | 6.85E-07 | 4.21E-06 | 0.44 | 0.67 |
| FRCONVT4_FI | 1.56E-05 | 2.24E-04 | 0.43 | 1.24 |
| VDFT4_FI | 1.21E-01 | 5.99E-01 | 0.33 | 0.64 |
| KDEGT4F_FI | 2.13E-03 | 5.47E-03 | 0.24 | 0.42 |
| QFRP_MI | 4.51E-01 | 8.37E-01 | 0.18 | 0.31 |
| PFT4PLC_MI | 5.93E-01 | 2.29E+00 | 0.14 | 0.25 |
| PPLCPF_MI | 1.65E-01 | 6.35E-01 | 0.09 | 0.25 |
| PAFT4PLCF_MI | 1.12E-04 | 4.48E-04 | 0.08 | 0.19 |
| PAFPLCBTOT_MI | 3.04E-02 | 1.30E-01 | 0.06 | 0.13 |
| PPLC_MI | 1.65E-01 | 6.35E-01 | 0.06 | 0.12 |
| VMAXNISF_THY_FI | 9.75E+02 | 6.82E+03 | 0.06 | 0.13 |
| BW_F | 2.53E+00 | 4.27E+00 | 0.03 | 0.09 |
| PAFPLCTTOB_MI | 3.04E-02 | 1.30E-01 | 0.02 | 0.04 |
| KPRODT4F_FI | 8.24E-05 | 3.18E-04 | 0.00 | 0.00 |
| IODSTORES_MG_MI | 6.81E+00 | 2.24E+01 | 0.00 | 0.00 |
| VMAXNISF_PLC_MI | 2.85E+02 | 1.22E+03 | 0.00 | 0.00 |
*
Parameter ranges optimized for physiologically plausible sampling space for global sensitivity analysis.