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. 2015;17(1):3–13.

Table 1.

Summary of 10 Peer-reviewed Studies Investigating the Four-kallikrein Panel of the 4Kscore Test in Multiple Cohorts Totaling 15,139 Subjects

4Kscore % Reduction
Study Trial Cohort Endpoint Subjects AUC (Intervention)
Vickers AJ et al28 ERSPC Not screened Bx histology 740 0.90 57 (Bx)
Benchikh A et al29 ERSPC Not screened Bx histology 262 0.87 49 (Bx)
Vickers A et al30 ERSPC Not screened Bx histology 2914 0.84 51 (Bx)
Vickers AJ et al31 ERSPC Screened Bx histology 1501 0.80 36 (Bx)
Vickers AJ et al32 ERSPC Screened Bx histology 1241 0.83 41 (Bx)
Gupta A et al33 ERSPC Prior biopsy Bx histology 925 0.87 82 (Bx)
Parekh DJ et al36 US Validation Screened Bx histology 1012 0.82 43 (Bx)
Study
Carlsson S et al34 ERSPC Post RP Radical prostatectomy 392 0.84 14 (RP)
histology
Vickers AJ et al42 MDC Not screened Prostate cancer: 792 0.82 42 (Bx)
any, palpable,
metastatic
Stattin P et al35 VIP Not screened Distant prostate 5360
cancer metastasis
Total subjects studied 15,139

AUC, area under the operating curve; Bx, biopsy; ERSPC, European Randomized Study of Prostate Cancer Screening; MDC, Malmö Diet and Cancer Study; RP,radical prostatectomy; VIP, Västerbotten Intervention Project.

4Kscore® Test; OPKO Lab, Nashville, TN.