Table 1.
Summary of 10 Peer-reviewed Studies Investigating the Four-kallikrein Panel of the 4Kscore Test in Multiple Cohorts Totaling 15,139 Subjects
| 4Kscore | % Reduction | |||||
|---|---|---|---|---|---|---|
| Study | Trial | Cohort | Endpoint | Subjects | AUC | (Intervention) |
| Vickers AJ et al28 | ERSPC | Not screened | Bx histology | 740 | 0.90 | 57 (Bx) |
| Benchikh A et al29 | ERSPC | Not screened | Bx histology | 262 | 0.87 | 49 (Bx) |
| Vickers A et al30 | ERSPC | Not screened | Bx histology | 2914 | 0.84 | 51 (Bx) |
| Vickers AJ et al31 | ERSPC | Screened | Bx histology | 1501 | 0.80 | 36 (Bx) |
| Vickers AJ et al32 | ERSPC | Screened | Bx histology | 1241 | 0.83 | 41 (Bx) |
| Gupta A et al33 | ERSPC | Prior biopsy | Bx histology | 925 | 0.87 | 82 (Bx) |
| Parekh DJ et al36 | US Validation | Screened | Bx histology | 1012 | 0.82 | 43 (Bx) |
| Study | ||||||
| Carlsson S et al34 | ERSPC | Post RP | Radical prostatectomy | 392 | 0.84 | 14 (RP) |
| histology | ||||||
| Vickers AJ et al42 | MDC | Not screened | Prostate cancer: | 792 | 0.82 | 42 (Bx) |
| any, palpable, | ||||||
| metastatic | ||||||
| Stattin P et al35 | VIP | Not screened | Distant prostate | 5360 | – | – |
| cancer metastasis | ||||||
| Total subjects studied | 15,139 |
AUC, area under the operating curve; Bx, biopsy; ERSPC, European Randomized Study of Prostate Cancer Screening; MDC, Malmö Diet and Cancer Study; RP,radical prostatectomy; VIP, Västerbotten Intervention Project.
4Kscore® Test; OPKO Lab, Nashville, TN.