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. 2015 Apr 24;6(6):443–452. doi: 10.1007/s13238-015-0154-4

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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BmK I increased Nav1.8 persistent currents. (A) The percentage of persistent current over the voltage from −40 mV to +30 mV (the value of persistent current (I_pc) divided by peak current (I_pk)) in the absence and presence of BmK I. The values of persistent current were averaged by the data selected from the last 20 ms of Nav1.8 activation current. (B) I_pc/I_pk at −5 mV were prominently enhanced under BmK I perfusion. (100 nmol/L: n = 6; 500 nmol/L: n = 6; 1 μmol/L: n = 10; control: n = 21; *P < 0.05, **P < 0.005, compared with control, respectively;^## P < 0.005, compared with 100 nmol/L)