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. 2015 Apr 24;6(6):443–452. doi: 10.1007/s13238-015-0154-4

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Increase of Nav 1.8 currents caused by BmK I was blocked in the presence of A-803467 (5 μmol/L). (A) Increase of Nav 1.8 currents caused by BmK I was blocked in the presence of A-803467. Effects of BmK I (500 nmol/L) and A-803467 on Nav1.8 current recorded in a small-sized DRG neurons (13.72 pF). Nav1.8 current was elicited by depolarizing steps to 0 from a holding potential of −60 mV. (B) Current traces selected from (A) as indicated. The inactivation current trace was changed (arrow). And the current was almost completely blocked by A-803467. All DRG neurons for aforementioned experiments were exposed to 500 nmol/L TTX