Figure 1.

The morphology of the dentate gyrus (DG) is altered in p75NTR^ExIV−/− mice. Compared to age-matched controls, the mean thickness of both, the molecular (A) and the granular (B) layer of the DG is increased in adult p75NTR^ExIV−/− mice as. In contrast, aged p75NTR^ExIV−/− mice show a slight, but insignificant increase in the mean thickness of the molecular (C) or granular layer (D) of the DG. A representative image of the thickness of granular and molecular layer of the upper leaf of the DG of an control animal is shown in (E) and a representative image of the thickness of the granular layer and molecular layer of the upper leaf of the DG of a p75NTR^ExIV−/− mouse is in (F). Scalebars: 100 μm.