Figure 2.

Expression of plasma miR-497 and miR-663b in clinical variables and ROC curves analysis. (a) for plasma miR-497 expression in clinical features and (b) for miR-663b; (c) for ROC curves analysis of each miRNA signature. Tumor grade included G1, G2 and G3; and tumor stage was divided into superficial (pT_a-pT₁) and invasive (pT₂-pT₄) stage. Statistically significant differences were determined using the Mann-Whitney U test. *P < 0.05 meant the plasma miRNAs were compared to the healthy controls’. The area under receiver operating characteristics (ROC) curve (AUC) value was calculated for distinguishing BC patients from normal control subjects.