Table 2. The occupancy of the bridging water and the average distances of hydrogen bonds with the bridging water involved for APV and DRV bound HIV-1 PR complex systems.

	WT-APV	Flap+-APV	Act-APV	WT-DRV	Flap+-DRV	Act-DRV
Occupancy (%)	19.3 ± 4.8	17.2 ± 5.8	24.8 ± 3.9	99.3 ± 1.0	98.7 ± 5.3	26.1 ± 6.4
Average Distance (Å)	3.02 ± 0.38	3.01 ± 0.28	3.00 ± 0.36	2.92 ± 0.19	2.98 ± 0.22	3.01 ± 0.34