Table 1. Baseline demographics cognitive, symptom and daily function measures for parallel groups analysis.
| Characteristics | N | Placebo first | N | Raloxifene first | P-value |
|---|---|---|---|---|---|
| Age | 39 | 34.0 (8.4) | 40 | 37.4 (7.3) | 0.06 |
| Education | 39 | 12.3 (2.2) | 40 | 12.9 (2.8) | 0.45 |
| Age of disease onset | 39 | 22.1 (6.3) | 40 | 24.1 (4.8) | 0.02 |
| Illness duration | 39 | 12.2 (7.2) | 40 | 13.4 (7.5) | 0.51 |
| Sex (number) | 39 | 40 | χ2=0.19 | ||
| Male | 27 | 22 | |||
| Female | 12 | 18 | |||
| Race (number) | 39 | 40 | χ2=0.36 | ||
| Caucasian | 33 | 35 | |||
| Asian | 3 | 1 | |||
| Caucasian/Asian | 3 | 2 | |||
| Other | 0 | 2 | |||
| CPZ equivalents | 39 | 530.4 (395.7) | 40 | 529.0 (501.8) | 0.98 |
| Premorbid and current IQ | |||||
| WAIS-III | 39 | 90.8 (12.1) | 40 | 91.7 (14.5) | 0.78 |
| WTAR | 39 | 102.4 (8.8) | 40 | 102.7 (8.9) | 0.91 |
| Cognitive tests | |||||
| WAIS-III-LNS | 39 | 7.8 (2.9) | 40 | 8.4 (2.7) | 0.40 |
| WMSR-LMI | 39 | 7.8 (3.6) | 40 | 7.2 (3.2) | 0.44 |
| WMSR-LMII | 39 | 6.1 (3.3) | 40 | 5.9 (3.0) | 0.76 |
| TMT-A | 28 | 35.3 (9.3) | 29 | 41.8 (11.4) | 0.02 |
| COWAT | 39 | 38.2 (10.6) | 40 | 36.0 (11.2) | 0.38 |
| Symptom and daily function | |||||
| PANSS | |||||
| Positive | 39 | 14.9 (4.3) | 40 | 15.1 (5.3) | 0.92 |
| Negative | 39 | 14.6 (7.0) | 40 | 14.7 (5.7) | 0.61 |
| General | 39 | 30.5 (8.1) | 40 | 31.7 (9.7) | 0.76 |
| Total | 39 | 60.0 (16.8) | 40 | 61.4 (17.5) | 0.72 |
| DASS | |||||
| Depression | 39 | 11.6 (10.2) | 40 | 12.2 (8.7) | 0.56 |
| Anxiety | 39 | 10.7 (8.4) | 40 | 9.2 (7.1) | 0.49 |
| Stress | 39 | 14.7 (9.8) | 40 | 13.6 (8.0) | 0.61 |
| SF-36v2 total | 38 | 115.2 (16.5) | 39 | 115.2 (19.5) | 1.00 |
| SQLS total | 37 | 45.1 (16.7) | 39 | 47.6 (16.8) | 0.52 |
Abbreviations: COWAT, Controlled Oral Word Association Test; CPZ, chlorpromazine; DASS, Depression Anxiety and Stress Scale; IQ, intelligence quotient; LNS, letter number sequencing; PANSS, positive and negative syndrome scale; SF-36v2, Short Form 36 Version 2 Health Survey Questionnaire; SQLS, Schizophrenia Quality of Life Scale; TMT-A, trail making test A; WAIS-III, Wechsler Adult Intelligence Scale 3rd Edition; WMSR-LMI, Wechsler Memory Scale Revised Logical Memory I; WMSR- LMII, Wechsler Memory Scale Revised Logical Memory II, WTAR, Wechsler Test of Adult Reading.
Unless otherwise specified, values refer to means and s.d. in parentheses.