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. 2015 May 6;2:15013. doi: 10.1038/mtm.2015.13

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Schematic diagram depicting the proposed role of proNGF/p75NTR in mediating EC death and development of acellular capillaries. Overexpression of proNGF impairs endogenous NGF/TrkA survival signaling pathway and activates p75NTR-mediated apoptotic signal. ProNGF triggers interaction of intracellular domain of p75NTR (p75^ICD) and the transcriptional factor neurotrophin interacting factor (NRIF) to activate JNK apoptotic signal. Targeting p75^NTR prevents the apoptotic signal and stimulates endogenous cell survival.