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. 2015 Mar 25;2:15007. doi: 10.1038/mtm.2015.7

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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GAA antibody titers following systemic AAV9-DES or continuous ERT therapy. Continuous enzyme replacement therapy (ERT) administration resulted in significant elevation of GAA antibody titers at 3 weeks, 2 months, and 3 months when compared to naive Gaa^–/–. ERT-generated GAA antibody titers were significantly increased at 2 months when compared to AAV9-DES treated Gaa^–/– animals. Values indicated are the mean ± SEM. ^#ERT = P ≤ 0.05 versus Gaa^–/–. ^##ERT = P ≤ 0.01 versus Gaa^–/–. ****AAV9-DES = P ≤ 0.0001 versus Gaa^–/–. ^####ERT = P ≤ 0.0001 versus Gaa^–/–. n.s., not significant; GAA, acid α-glucosidase.