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. 2015 Apr 8;2:15011. doi: 10.1038/mtm.2015.11

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Expression of pancreatic hormones following reversal of diabetes in NOD/scid mice following transplantation of Melligen cells. (a–c) Photomicrographs of triple anti-insulin (INS), anti-somatostatin (SST), and anti-glucagon (GLUC) staining of (a) Melligen graft, (b) normal mouse pancreas, and (c) diabetic mouse pancreas; original magnification, 400×. (d) Transmission electron micrograph showing secretory vesicles with dense granules (g) (bar = 250 nm) in Melligen grafts, 30 days after transplant. (e) Immunoelectron micrograph showing localization of insulin in Melligen grafts, 30 days after transplant (bar = 300 nm).