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. 2015 May 27;5:10637. doi: 10.1038/srep10637

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Copyright © 2015, Macmillan Publishers Limited

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Alignment of the condensation (C) domain core motifs of Ces and core motifs from selected bacterial NRPS. SrfAC: terminal C domain from surfactin synthetase as representative of a DCL; NocB: C5 domain from the nocardicin synthetase as representative of a C domain with non-canonical functions; Vlm1: C2 domain in the valinomycin synthetase, which shows the same genetic architecture as the cereulide synthetase; Crp_D: C domain (M2) from cryptophycin synthetase catalyzing ester bound formation; EntF: C domain from enterobactin synthetase. According to literature⁴², the consensus sequence from Pfam database for core motifs C1 to C5 is depicted. The C3 core motif comprises the conserved catalytic motif HHxxxDG (printed in bold).