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. 2014 Oct 13;5(5):114. doi: 10.1186/scrt504

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© Brennan et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Optimal cell dosage for ectopic bone formation. (a) Masson trichrome staining shows biphasic calcium phosphate biomaterial (BCP, gray) in contact with newly formed bone (B, green). Mature bone marrow territories (BM) were present after 8 weeks. Scale bars: 2.5 mm and 250 μm for images in the left and right columns respectively. (b) Histomorphometry revealed significantly more bone in the 2 × 10⁶ to 4 × 10⁶ cell groups compared with the empty scaffolds (^a P <0.02) and compared with the 0.1 × 10⁶ cell group (^b P <0.02). (c) Bone marrow territories were present only in the 2 × 10⁶ and 4 × 10⁶ cell groups, but there was no statistical difference between groups. BMSCs, bone marrow stromal cells.