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. 2014 Oct 13;5(5):114. doi: 10.1186/scrt504

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© Brennan et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ectopic bone formation of freshly transported batches of bone marrow stromal cells. (a), (b) In backscattered electron imaging, the biphasic calcium phosphate (BCP) ceramic and mineralized bone can be differentiated by their relative gray densities. The BCP particles were surrounded by a well-mineralized lamellar bone tissue in the BCP + BMSCs group after 8 weeks. (c) Masson trichrome staining showed bone formation (B) at the periphery of the explants that contained bone marrow compartments (BM). (d) Histomorphometry of Masson trichrome staining sections revealed significant differences in the bone induction capacity between human donors. ^aStatistically lower compared to Donor 4 (P <0.05). ^bStatistically lower compared with to Donor 5 (P <0.05). BMSCs, bone marrow stromal cells.