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. 2014 Oct 13;5(5):114. doi: 10.1186/scrt504

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© Brennan et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Bioluminescence imaging of luciferase-expressing bone marrow stromal cells. (a) Representative bioluminescence imaging (BLI) for a control group that received biphasic calcium phosphate (BCP) alone on their left dorsal side and subcutaneous (SC) injections of bone marrow stromal cells (BMSCs) on their right dorsal side, and the experimental group that received subcutis implantations of BCP + BMSCs. (b) The BLI signal, expressed as counts per minute (cpm), decreased after transplantation, while BCP dampened the BLI signal. (c) When the number of remaining cells compared with the number of initially transplanted cells was expressed at each time point, SC implantation of BCP + BMSCs was significantly higher from day 8 onwards compared with the SC injections group (^a P <0.01). Approximately 1.5% of the initial number of transplanted cells in the SC BCP + BMSCs group remained at day 37.