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. 2014 Oct 13;5(5):114. doi: 10.1186/scrt504

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© Brennan et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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In situ hybridization using the human-specific repetitive Alu sequence for identification of human cells. All samples were analyzed after 8 weeks of subcutaneous implantation in nude mice (a) Negative control. (b) Although explants were composed primarily of mouse cells (purple nuclei), human cells (brown/black) were identified attached along the periphery of biphasic calcium phosphate (BCP) particles (red arrows). These regions of interest are shown in magnified view. (c) Masson trichrome staining of explants with a serial section showing human cells present (red arrow), with a magnified view also presented. (d) Explant showing mice cells (purple nuclei) and human cells (brown/black nuclei) embedded in osteocyte lacunae and surrounding BCP particles (red arrows). Scale bars: 250 μm. B, bone formation.