Table 1.

Chemokine receptor expression and ligand responses on circulating human NKT cells.

Receptor	Expression (%)a			Chemotactic responsec	Reference
	CD4+	DNb	CD8+
CCR1d	2–25	55–85	30–80	CD4+; DN++; CD8++	(87, 89)
CCR2d	60–80	95–99	65–99	+++	(87, 89)
CCR3	0–4	0–4	0–4	n.d.	(87, 89)
CCR4	12–40	4–18	2–10	CD4++; DN+; CD8−	(87, 89)
CCR5	45–80	90–99	70–99	+	(4, 87, 89, 116)
CCR6	10–68	72–95	50–85	CD4+; DN+++; CD8+++	(87, 89, 116)
CCR7	11–28	7–32	2–25	++	(4, 87, 89)
CCR8	11–55% total NKT cells			−	(89, 140)
CCR9	0–4	0–4	0–4	−	(87, 89)
CCR10e	n.d.	n.d.	n.d.	−	(89)
CXCR1	5–10	3–8	n.d.	−	(89)
CXCR2	0–2	0–1	n.d.	−	(89)
CXCR3	75–90	95–99	80–90	+++	(4, 87, 89)
CXCR4	90–99	98–99	95–99	+++	(4, 87, 89)
CXCR5	0–4	0–4	0–4	−	(87, 89)
CXCR6	22–45	85–99	60–98	++	(87, 89, 116)
CX3CR1	4–12	4–12	n.d.	−	(89)

^aRange in reported frequency of receptor positive NKT cells.

^bDN = CD4⁻CD8⁻double negative NKT cells.

^cNet chemotactic migration: − (did not respond), + (2–10%), ++ (11–30%), and +++ (>30%).

^dOthers report CCR1 and CCR2 on <2% of NKT cells (89, 116).

^eCCR8 and CCR10 mRNA detected in NKT cell subsets (89).

n.d. – not determined.