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. 2015 May 27;6:244. doi: 10.3389/fimmu.2015.00244

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Copyright © 2015 Tobar, Arancibia, Torres, Vera, Soto, Carrasco, Alvarado, Neira, Arcos and Tobar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Several oral immunizations are required to maintain a long-term protection against SRS. Salmonids from different aquaculture industries were first immunized with an injectable mono or polyvalent vaccine against SRS. The arrows at 1700 and 2900 degree-days indicate the time-point where first and second oral vaccines were administrated, respectively. Serum samples were obtained at different degree-days to determine specific IgM anti-P. salmonis. Samples were statistically analyzed by one-way ANOVA – Dunnet post-test. (SRS 150 fish/point, ISAv 70 fish/per point) *p < 0.05; **p < 0.01; ***p < 0.001.