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. 2015 May 27;9:192. doi: 10.3389/fncel.2015.00192

Figure 1.

Figure 1

Aromatase inhibition and ER antagonism prevent the induction but not the maintenance of MSN LTP while basal membrane properties are unaffected. (A,C) Voltage traces recorded from MSNs during the injection of hyperpolarizing and depolarizing steps of currents in control conditions (left) and in the presence of LET (A, right) or ICI (C, right). (B,D) Voltage-current plots of MSNs membrane potentials acquired in control conditions (white circles) and in the presence of LET (B, black circles) and ICI (D, black diamonds). (E) EPSP pairs of traces recorded from striatal MSNs before and after the application of a HFS protocol in control conditions (left traces) and in the presence of 100 nM letrozole (LET, right traces, top) or 100 nM ICI-182,780 (ICI, right traces, bottom). The time-courses show the effect of HFS (arrow) applied in control condition (white circles) and in the presence of LET (black circles) or ICI (grey circles) on the EPSP amplitude. (F) EPSP pairs recorded before and after HFS application in control conditions (left) and in the presence of LET (top) or ICI (bottom) applied 15 minutes after the HFS (black bar). The time-courses show the effect of LET or ICI on the maintenance of HFS-LTP. Note that LTP induction, but not the maintenance, is prevented in the presence of LET or ICI.