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. 2015 May 27;9:192. doi: 10.3389/fncel.2015.00192

Figure 5.

Figure 5

Involvement of cAMP-PKA pathway in the D1R-dependent MSN LTP in the presence of aromatase inhibition and ER antagonism. (A) EPSC traces recorded from MSNs before and after the HFS in control conditions and in the presence of ICI and ICI plus 100 μM 8-Br-cAMP. Graph shows the time-course of the HFS effect on the amplitude of EPSC recorded in control conditions, in the presence of ICI and ICI plus 8-Br-cAMP. (B) EPSC traces and time-course graph of HFS effect in the presence of ICI plus 8-Br-cAMP and ICI plus 8-Br-cAMP plus 100 μM RP-cAMPS. (C) EPSC pairs of traces and time-course of HFS effect on EPSC amplitudes acquired in the presence of LET plus SKF and LET plus RP-cAMPS plus SKF. (D) EPSC pairs and time-course of the effect of 100 nM E2 applied in the presence of 100 nM LET or in the presence of LET plus 100 μM RPcAMPS. (E) EPSP pairs and time-course of HFS effect on EPSP amplitudes recorded in the presence of LET plus SKF and LET plus SKF plus 10 μM PD98059.