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. Author manuscript; available in PMC: 2015 May 27.
Published in final edited form as: Annu Rev Immunol. 2014 Dec 10;33:139–167. doi: 10.1146/annurev-immunol-032713-120211

Figure 2.

Figure 2

Cytokine receptor–ligand engagement, dimerization, and signaling. A cytokine interaction with its cognate receptor is shown, based on the structure of the IL-4 receptor signaling complex. This complex is representative of the dimeric unit mediating canonical JAK/STAT cytokine receptor signaling, forming site 1 and site 2 contacts to dimerize the receptors and initiate JAK/STAT signaling.