Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1973 Sep;4(3):270–276. doi: 10.1128/aac.4.3.270

Serum Antibiotic Concentrations Pre- and Postcardiopulmonary Bypass

Ronica M Kluge 1, Frank M Calia 1, Joseph S McLaughlin 1, Richard B Hornick 1
PMCID: PMC444540  PMID: 4758833

Abstract

Serum concentrations of cephalothin or kanamycin, or both, were determined in 53 patients undergoing cardiopulmonary bypass. Conventional doses of these antibiotics did not provide serum levels above the accepted minimum inhibitory concentrations in children. Adults had adequate serum antibiotic concentrations only when the antimicrobials were administered within 4 h of beginning cardiopulmonary bypass. The impact of these variations upon the occurrence of infectious endocarditis could not be appraised since no cases of infective endocarditis were seen during a 4-month postoperative period.

Full text

PDF
270

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amoury R. A., Bowman F. O., Jr, Malm J. R. Endocarditis associated with intracardiac prostheses. Diagnosis, management, and prophylaxis. J Thorac Cardiovasc Surg. 1966 Jan;51(1):36–48. [PubMed] [Google Scholar]
  2. Benner E. J. Metabolism of antibiotics during cardiopulmonary bypass for open-heart surgery. Antimicrob Agents Chemother (Bethesda) 1968;8:373–377. [PubMed] [Google Scholar]
  3. Blakemore W. S., McGarrity G. J., Thurer R. J., Wallace H. W., MacVaugh H., 3rd, Coriell L. L. Infection by air-borne bacteria with cardiopulmonary bypass. Surgery. 1971 Dec;70(6):830–838. [PubMed] [Google Scholar]
  4. Braimbridge M. V. Cardiac surgery and bacterial endocarditis. Lancet. 1969 Jun 28;1(7609):1307–1309. doi: 10.1016/s0140-6736(69)92239-9. [DOI] [PubMed] [Google Scholar]
  5. Burke J. F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961 Jul;50:161–168. [PubMed] [Google Scholar]
  6. Conte J. E., Jr, Cohen S. N., Roe B. B., Elashoff R. M. Antibiotic prophylaxis and cardiac surgery. A prospective double-blind comparison of single-dose versus multiple-dose regimens. Ann Intern Med. 1972 Jun;76(6):943–949. doi: 10.7326/0003-4819-76-6-943. [DOI] [PubMed] [Google Scholar]
  7. Fekety F. R., Jr, Cluff L. E., Sabiston D. C., Jr, Seidl L. G., Smith J. W., Thoburn R. A study of antibiotic prophylaxis in cardiac surgery. J Thorac Cardiovasc Surg. 1969 Jun;57(6):757–763. [PubMed] [Google Scholar]
  8. Firor W. B. Infection following open-heart surgery, with special reference to the role of prophylactic antibiotics. J Thorac Cardiovasc Surg. 1967 Mar;53(3):371–378. [PubMed] [Google Scholar]
  9. Gooch A. S., Maranhao V., Alblaza S., Goldberg H. Medical complications following open-heart surgery. Arch Intern Med. 1967 Dec;120(6):672–678. doi: 10.1001/archinte.120.6.672. [DOI] [PubMed] [Google Scholar]
  10. Goodman J. S., Schaffner W., Collins H. A., Battersby E. J., Koenig M. G. Infection after cardiovascular surgery. Clinical study including examination of antimicrobial prophylaxis. N Engl J Med. 1968 Jan 18;278(3):117–123. doi: 10.1056/NEJM196801182780301. [DOI] [PubMed] [Google Scholar]
  11. HERR R., STARR A., MCCORD C. W., WOOD J. A. SPECIAL PROBLEMS FOLLOWING VALVE REPLACEMENT: EMBOLUS, LEAK, INFECTION, RED CELL DAMAGE. Ann Thorac Surg. 1965 Jul;1:403–415. doi: 10.1016/s0003-4975(10)66776-8. [DOI] [PubMed] [Google Scholar]
  12. Hughes R. K. A method of improved antisepsis for open-heart surgery. Ann Thorac Surg. 1966 Mar;2(2):230–236. doi: 10.1016/s0003-4975(10)66568-x. [DOI] [PubMed] [Google Scholar]
  13. Manko M. A., Birkhead N. C., Bodi T., Donnelly J. C., Haupt G. J. Cephaloridine prophylaxis in open heart surgery. Curr Ther Res Clin Exp. 1972 Oct;14(10):679–686. [PubMed] [Google Scholar]
  14. Rothlin M., Baumann P. C., Ratti R., Senning A. Infectious endocarditis following cardiac surgery. Ger Med Mon. 1969 Nov;14(11):539–passim. [PubMed] [Google Scholar]
  15. WILSON T. S., STUART R. D. STAPHYLOCOCCUS ALBUS IN WOUND INFECTION AND IN SEPTICEMIA. Can Med Assoc J. 1965 Jul 3;93:8–16. [PMC free article] [PubMed] [Google Scholar]
  16. Yeh T. J., Anabtawi I. N., Cornett V. E., White A., Stern W. H., Ellison R. G. Bacterial endocarditis following open-heart surgery. Ann Thorac Surg. 1967 Jan;3(1):29–36. doi: 10.1016/s0003-4975(10)66684-2. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES