Figure 4.

Coherence analysis comparisons of integration site (IS) patterns in transduced CD34⁺ cells and peripheral blood mononuclear cells from patients treated for SCID-X1. Integration site datasets were randomly subsampled to match the size of the SCID1_London dataset (3,870 ISs). (a) Whole-genome coherence values are plotted for comparisons of IS patterns between the P, L, SCID1_Paris and SCID1_London datasets. (b) The distributions of coherence values representing the individually plotted values in panel (a) and additional intra-dataset comparisons are represented as Tukey box plots:³⁶ lower and upper bounds of boxes depict the first and third quartiles, respectively; the horizontal lines in the boxes indicate the median coherence values; bottom and top whiskers represent values corresponding to 1.5× the interquartile range of the lower and upper quartiles, respectively; and outliers and extreme values are not shown. Whole-genome comparisons comprise 8,191 data points. ****P < 0.0001 for comparison of median coherence values by Wilcoxon matched-pairs signed rank test (only shown for two selected statistical comparisons referred to in Results).