Table 2.
Quantitative parameters of hepatocyte measurements in healthy Balb/c mice and mice bearing 4T1 breast carcinoma without treatment or treated with Rh2Cit, Magh-Rh2Cit, and Magh-Cit
| Groups | Healthy | Control | Rh2Cit | Magh-Rh2Cit | Magh-Cit |
|---|---|---|---|---|---|
| Hepatocyte area (μm2) | 84.7 ± 21.1 | 85.7 ± 7.8 | 72.3 ± 12.9 | 83.5 ± 10.4 | 75.3 ± 12.7 |
| Hepatocyte volume (μm3) | 600.3 ± 234.1 | 599.2 ± 85.8 | 468.9 ± 129.0 | 577.5 ± 116.5 | 497.1 ± 131.0 |
| Cytoplasm area (μm2) | 75.6 ± 20.3 | 72.0 ± 7.6 | 62.5 ± 11.9 | 73.4 ± 9.3 | 66.1 ± 12.0 |
| Cytoplasm volume (μm3) | 508.2 ± 201.4 | 462.0 ± 73.0 | 376.9 ± 105.0 | 476.3 ± 91.6 | 409.9 ± 109.5 |
| Cytoplasmic/nuclear ratio (μm2) | 8.3 ± 1.6 | 5.2 ± 1.7 | 6.32 ± 2 | 7.2 ± 1.8 | 7.2 ± 1.1 |
| Nucleus area (μm2) | 9.0 ± 1.6 | 13.7 ± 1.7*a | 9.8 ± 2.0*b | 10.0 ± 1.8*b | 9.1 ± 1.1*b |
| Diameter of nucleus (μm) | 3.7 ± 0.2 | 4.1 ± 0.4 | 4.0 ± 0.3 | 4.0 ± 0.3 | 3.9 ± 0.3 |
| Nucleus volume (μm3) | 20.8 ± 5.3 | 38.3 ± 7.3*a | 23.7 ± 7.6*b | 24.3 ± 6.7*b | 20.9 ± 3.8*b |
Letters indicate significant differences in 2-by-2 comparisons detected by the Tukey test, with a = significant compared to the healthy group and b = significant compared to the control group. Results are expressed as mean ± SE of the mean
*p < 0.05