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. 2015 May 27;10:30. doi: 10.1186/s13062-015-0049-6

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© Könnyű et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The Metabolically Coupled Replicator System with folded RNA molecules. A: The MCRS concept: M represents the hypothetical metabolic reaction network (metabolism). All reactions of M are catalysed by different replicators with enzymatic activities {1} (blue arrow), {2} (red arrow) and {3} (green arrow). The metabolism produces monomers (yellow arrows) which are the common resource of all replicator types (solid arrows). Each replicator is folded into 2D structures (dashed arrows) which may acquire catalytically active (coloured) regions including “active” and “helper” (boldface) bases. A parasitic sequence not contributing to monomer production (no arrow to M) but consuming monomers, is shown in white (no enzymatically active region). B: Colours represent catalitically active regions within a sequence; α is the catalytic efficiency of the given region (detailed explanation in text).